Enantioselective copper-catalyzed construction of aryl pyrroloindolines via an arylation-cyclization cascade.
نویسندگان
چکیده
An enantioselective arylation-cyclization cascade has been accomplished using a combination of diaryliodonium salts and asymmetric copper catalysis. These mild catalytic conditions provide a new strategy for the enantioselective construction of pyrroloindolines, an important alkaloid structural motif that is commonly found among biologically active natural products.
منابع مشابه
C2sc20914d 3170..3174
The pyrroloindoline alkaloids are a structurally diverse family of biologically active natural products, which include compounds such as hodgkinsine (1), naseseazine A (2), and gliocladine C (3) 3 (Fig. 1). As a result of their compelling bioactivities and fascinating structures, this family of alkaloids has been the subject of intense research and has inspired the development of a variety of n...
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ورودعنوان ژورنال:
- Journal of the American Chemical Society
دوره 134 26 شماره
صفحات -
تاریخ انتشار 2012